CARDARINE GW501516 Powder

GW-501516 Raw Powder Italy

GW-501516, also known as Cardarine, is a potent and selective PPARβ agonist that offers a range of potential benefits. This compound has generated significant interest within the Italy fitness and bodybuilding communities due to its reported effects on muscle-building, endurance, fat loss and overall metabolic enhancement.

One of the key beneficial effects associated with GW-501516 is its ability to stimulate fatty acid metabolism, thereby boosting the body’s capacity to burn stored fat for energy. This can contribute to improved endurance and stamina, making it an attractive option for individuals looking to enhance their athletic performance.

Additionally, GW-501516 has been linked to positive effects on HDL cholesterol levels, indicating a potential role in promoting cardiovascular health. Furthermore, it may have a favourable impact on insulin sensitivity and glycogen storage, which could be advantageous for individuals aiming to improve their metabolic profile and overall health.

It’s important to note that GW-501516 is not a SARM (Selective Androgen Receptor Modulator) but has often been mistakenly categorized as one. Despite this, its reported benefits and potential applications have led to widespread interest in the compound within the fitness and wellness communities. Its high affinity for the PPARδ receptor has also made it a compound of interest in studies focused on gene expression, cell growth, and endothelial cells function.

Benefits of GW-501516 Raw Powder Italy

GW-501516, also known as Cardarine, offers several advantages for Italy scientific researchers and medical professionals seeking to enhance their understanding of fat metabolism, muscle performance, and tissue regeneration.

Fat Burning

GW-501516 can effectively burn fat by activating the PPARδ receptor, leading to significant increase in the oxidation of fatty acids and, in some cases, a significant decrease in lipid accumulation. This activation stimulates the genes involved in energy expenditure, promoting the body’s ability to utilize stored fat as a primary fuel source.

As a result, GW-501516 enhances metabolic processes, encourages the use of fat for energy production, and improves endurance during physical activities. These combined effects make it a promising compound for those seeking to enhance fat-burning capabilities, potentially supporting weight loss, body weight control and overall metabolic health.

Supports muscle endurance and hypertrophy

GW-501516 supports muscle endurance and hypertrophy through its ability to enhance oxidative metabolism and increase the expression of genes involved in skeletal muscle fiber development. By activating the PPARδ receptor, it stimulates the utilization of fatty acids for energy, sparing glycogen stores and prolonging physical performance.

This can lead to improved endurance during workouts and training sessions. Additionally, the compound’s potential to promote the development of type I muscle fibers may contribute to overall muscle hypertrophy and endurance. Italy Studies in cell lines and animal studies also support its role in regulating metabolic pathways related to energy use and performance.

Cholesterol Benefits

GW-501516 research has shown promising effects on cholesterol levels. Italy Clinical studies indicates that it can significantly increase high-density lipoprotein (HDL) cholesterol, the “good” cholesterol, by up to 16.9%. Additionally, it may reduce low-density lipoprotein (LDL) cholesterol, often referred to as the “bad” cholesterol. These lipid-modulating properties suggest a potential role for GW-501516 in promoting cardiovascular health by improving the balance of cholesterol in the body.

By enhancing HDL levels and potentially reducing LDL levels, GW-501516 may offer valuable support for those aiming to optimize their lipid profile and overall cardiovascular well-being, including those with fatty liver disease risk factors. Recent study data also highlight effects on central nervous system pathways and adverse events tracking compared with such drugs used in metabolic research.

Improves glycogen storage and insulin sensitivity

GW-501516 offers potential benefits related to glycogen use and insulin sensitivity. Italy Research suggests it may help preserve glycogen during exercise by promoting fatty acid utilization as the primary energy source. Additionally, it has been associated with enhanced insulin sensitivity, which is crucial for regulating blood sugar levels and supporting efficient nutrient uptake by cells.

By influencing these metabolic mechanisms, the compound shows promise in optimizing energy reserves, supporting muscle function, and enhancing overall metabolic health. Further studies and testing, including standard tests such as a urine test, are assessing its role in comparison with other agents like thyroid hormone receptor modulators.

While GW-501516 shows potential, long term side effects remain a research concern. Clinical development is still ongoing to better understand its safety profile, particularly at varying daily dose levels and across different subject groups.

What Are the Side Effects of GW-501516 Raw Powder?

Italy Studies investigating GW-501516 have reported potential safety concerns that require careful consideration. At elevated doses in animal models, the compound has been linked to tumor development, prompting caution in ongoing research. Other reports highlight possible impacts on lipid metabolism and liver function, underscoring the importance of controlled laboratory evaluation.

GW-501516 Raw Powder is an investigational compound supplied strictly for research purposes only. It is not FDA-approved and is not intended for human use. Continued scientific studies are essential to fully understand both its potential applications and associated risks.

Like our GW501516 Powder SARM? Shop more GW-501516 products here from Direct SARMS Italy

References:

[1] Turza A, Pascuta P, Muresan-Pop M, Mare L, Borodi G, Popescu V. Five Novel Polymorphs of Cardarine/GW501516 and Their Characterization by X-ray Diffraction, Computational Methods, Thermal Analysis and a Pharmaceutical Perspective. Pharmaceutics. 2024 May 7;16(5):623.

[2] Turza A, Bosca M, Muresan-Pop M, Mare L, Borodi G, Popescu V. Novel Solid Forms of Cardarine/GW501516 and Their Characterization by X-Ray Diffraction, Thermal, Computational, FTIR, and UV Analysis. Pharmaceutics. 2025 Jan 23;17(2):152.

[3] Dimopoulos N, Watson M, Green C, Hundal HS. The PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells. FEBS Lett. 2007 Oct 2;581(24):4743-8.

[4] Aguilar-Recarte D, Palomer X, Wahli W, Vázquez-Carrera M. The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance. Int J Mol Sci. 2021 Aug 9;22(16):8555.

[5] Olson EJ, Pearce GL, Jones NP, Sprecher DL. Lipid effects of peroxisome proliferator-activated receptor-δ agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2289-94.

[6] Risérus U, Sprecher D, Johnson T, Olson E, Hirschberg S, Liu A, Fang Z, Hegde P, Richards D, Sarov-Blat L, Strum JC, Basu S, Cheeseman J, Fielding BA, Humphreys SM, Danoff T, Moore NR, Murgatroyd P, O’Rahilly S, Sutton P, Willson T, Hassall D, Frayn KN, Karpe F. Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men. Diabetes. 2008 Feb;57(2):332-9.

Molecular Formula: 
 C21H18F3NO3S2
Molecular Weight: 453.498 g/mol

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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Italy Direct Sarms website is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.